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10.1016/S1474-4422(09)70014-6 106 WuB.TengH.ZhangL.LiH.LiJ.WangL.et al (2015)

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It was designed as an improvement to an older peptide, Argireline , and works by targeting dynamic wrinklesthe ones caused by repeated facial expressions

Some other factors may include: Consuming hot foods/beverages Genetic predisposition Sunlight overexposure Emotional stress Autoimmunity Overheating Vitamin D status Zinc levels Anxiety Rosacea in Skin of Colour Inaccurately, there can be the common misconception that darker skin tones do not present with rosacea

If you are dealing with worse sleep disturbances, maybe youre in a structured therapeutic or research situation, are okay with injections, and you want a more potent and fast-acting route, then injectable DSIP could be the better fit